01 - Set oven to 400°F and line a baking sheet with parchment paper.
02 - Whisk together flour, granulated sugar, baking powder, and salt in a large bowl.
03 - Add cold cubed butter to dry ingredients and cut in using a pastry cutter or fingertips until mixture resembles coarse crumbs.
04 - Whisk egg, heavy cream, orange zest, and vanilla extract together in a separate bowl.
05 - Pour wet ingredients into dry and gently stir until just combined, avoiding overmixing.
06 - Fold cranberries evenly into the dough.
07 - Transfer dough to a lightly floured surface and pat into a 7-inch diameter circle approximately 1 inch thick.
08 - Cut the circle into 8 equal wedges and arrange them spaced apart on the prepared baking sheet.
09 - Lightly brush the tops of each wedge with heavy cream.
10 - Bake for 16 to 18 minutes until scones are golden brown. Transfer to a wire rack to cool.
11 - Whisk powdered sugar, orange juice, and orange zest until smooth. Drizzle glaze over cooled scones and allow to set before serving.